Research Articles
Unlocking Nature's Code: Advanced Strategies for RiPP Biosynthetic Gene Cluster Discovery and Characterization
This comprehensive guide for researchers and drug discovery professionals details the latest strategies for the discovery and analysis of Ribosomally synthesized and post-translationally modified peptide (RiPP) biosynthetic gene clusters (BGCs).
Advanced RiPP Bioactivity Screening Strategies: A Comprehensive Guide for Targeting Gram-Positive Pathogens
This comprehensive guide details the complete workflow for screening Ribosomally synthesized and Post-translationally modified Peptides (RiPPs) for activity against high-priority Gram-positive pathogens, including MRSA, VRE, and *Clostridioides difficile*.
Rhodococcus jostii RHA1: Advanced Genome Editing of the PET Hydrolase for Bioremediation and Biocatalysis
This article provides a comprehensive guide for researchers and biotechnologists on the genome editing of Rhodococcus jostii RHA1, with a focus on engineering its polyethylene terephthalate (PET) hydrolase (RPET).
RetroTRAE: A Deep Dive into Atom-Environment Based Retrosynthesis Prediction for Accelerated Drug Discovery
This article provides a comprehensive overview of RetroTRAE, a cutting-edge retrosynthesis prediction tool that leverages atomic environments.
Automating Bioprocess Analysis: A Guide to the ReacSight Strategy for Real-Time, In-Line Bioreactor Monitoring
This article provides researchers, scientists, and drug development professionals with a comprehensive guide to implementing the ReacSight strategy for automated bioreactor measurements.
ReCiPe: The Essential Guide to Biosynthetic Route Assessment for Sustainable Pharma Development
This article provides a comprehensive guide to the ReCiPe (Resource Consumption and Environmental Impact) methodology, a leading life cycle assessment framework specifically tailored for evaluating the environmental and economic sustainability...
A Comprehensive Guide to RT-qPCR for Biosynthetic Gene Analysis: From Fundamentals to Advanced Validation in Drug Discovery
This article provides a complete methodological framework for utilizing Reverse Transcription Quantitative Polymerase Chain Reaction (RT-qPCR) in the analysis of biosynthetic gene expression.
RODEO Algorithm: A Complete Guide for Accelerated RiPP Biosynthetic Gene Cluster Discovery
This comprehensive article explores RODEO (Rapid ORF Description and Evaluation Online), a pivotal computational tool for identifying Ribosomally synthesized and post-translationally modified peptide (RiPP) precursor peptides and their biosynthetic gene...
READRetro: The Ultimate Guide to AI-Powered Retrosynthesis for Drug Discovery Researchers
This comprehensive guide explores READRetro, a powerful retro web platform for computer-aided retrosynthesis planning.
PolE and PolF Genes: Key Enzymes in the Polyoxin Biosynthetic Pathway and Their Antifungal Potential
This article provides a comprehensive overview of the PolE and PolF genes, their crucial enzymatic roles in the biosynthesis of the nucleoside antibiotic polyoxin, and their implications for antifungal drug...